Quick Answer: How Many Types Of Charcot Marie Tooth Disease Are There?

What is Charcot Marie Tooth disease Type 2?

Charcot-Marie-Tooth disease type 2 (CMT2) is a type of CMT with genetic defects that disrupt the structure and function of the axons of the peripheral nerves.

So, CMT2 often is referred to as “axonal CMT.” CMT2 is less common than CMT1 and accounts for about one-third of all dominant CMT cases..

Can CMT affect your eyes?

CMT Type 6 involves development of optic atrophy with loss of vision or blindness, muscle atrophy and weakness, loss of sensation, and balance and gait difficulties. Depending on the genetic cause of the CMT Type 6, there may be other symptoms including delayed learning.

Does CMT affect your brain?

Unlike other neurological disorders, CMT usually isn’t life-threatening, and it almost never affects the brain. It causes damage to the peripheral nerves — tracts of nerve cell fibers that connect the brain and spinal cord to muscles and sensory organs.

What causes Charcot Marie Tooth?

CMT is caused by mutations in genes that support or produce proteins involved in the structure and function of either the peripheral nerve axon or the myelin sheath. More than 40 genes have been identified in CMT, with each gene linked to one or more types of the disease.

How many types of CMT are there?

The different types of CMT disease are CMT1, CMT2, CMT3, CMT4, CMTX, and DI-CMT.

What does Charcot Marie Tooth disease look like?

Charcot-Marie-Tooth disease is also called hereditary motor and sensory neuropathy. Charcot-Marie-Tooth disease results in smaller, weaker muscles. You may also experience loss of sensation and muscle contractions, and difficulty walking. Foot deformities such as hammertoes and high arches also are common.

Does CMT make tired?

Fatigue is a common symptom in CMT. A study, published in the Journal of Neurology in 2010 and based on questionnaire given patients and an age- and sex-matched control group, reported that fatigue levels were significantly higher in people with CMT. Fatigue in CMT can be due to a number of reasons.

How is Charcot Marie Tooth passed on?

CMTX is inherited in an X-linked dominant pattern . A condition is considered X-linked if the mutated gene that causes the disorder is located on the X chromosome. The inheritance is dominant if one copy of the altered gene is sufficient to cause the condition.

Is Charcot Marie Tooth a form of MS?

Charcot-Marie-Tooth disease type X (CMTX) may increase the risk of developing multiple sclerosis (MS), the most common central nervous system inflammatory demyelinating disease, according to data from a Greek study.

What age is Charcot Marie Tooth diagnosed?

The symptoms of CMT usually start to appear between the ages of 5 and 15, although they sometimes do not develop until well into middle age or later.

Is CMT considered a disability?

Medically Qualifying Under A Disability Listing: CMT is a form of peripheral neuropathy, meaning it affects the nerves and muscles in the arms, legs, hands, and feet. The Social Security Administration (SSA) has a standard disability listing for this type of neurological disorder.

Is CMT more common in males or females?

The condition affects an equal number of males and females. CMT hereditary neuropathy is the most common inherited neurological disorder affecting more than 250,000 Americans. Since this condition is frequently undiagnosed, misdiagnosed or diagnosed very late in life, the true number of affected persons may be higher.

Is Charcot Marie Tooth painful?

Because CMT causes damage to sensory nerve fibers (axons), people with CMT can feel tingling and burning sensations in the hands and feet, usually causing only mild discomfort but sometimes causing pain. The sense of touch is diminished, as is the ability to sense changes in temperature.

Can you drive with CMT?

Driving ability and CMT Many CMT patients are able and allowed to drive. But the privilege of earning a driver’s license depends on the physical abilities of the individual patient. These skills vary among patients, and are affected by the type of CMT a person has.

Does Charcot Marie Tooth get worse?

Charcot-Marie-Tooth (CMT) affects the peripheral nerves. These are the nerves outside the main central nervous system (CNS). They control the muscles and relay data from the arms and legs to the brain, allowing a person to sense touch. It is a progressive condition, which means that symptoms get worse over time.